A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus strain
Lin, A.; Fang, Y.; Zhu, T.; Gu, Q.; Zhu, W.
Die Pharmazie 63(4): 323-325
2008
ISSN/ISBN: 0031-7144 PMID: 18468397 Document Number: 621095
A new diketopiperazine alkaloid containing the uncommon amino acid L-7, 9-dihydroxy-8-methoxyphenylalanine (1), has been isolated from the algicolous Aspergillus flavus strain. The structure of 1 including the absolute stereochemistry was determined by spectroscopic data and chemical means. Compound 1 showed weak cytotoxicity against HL-60 cell lines with an IC50 value of 36.5 microg/ml.
Document emailed within 1 workday
Related Documents
El-Tawila, M.M.; Ibrahim, N.A.; Gomaa, N.F.; Omar, R.M. 2003: The effect of bread making steps on the degradation of aflatoxins produced as a result of single inoculation with Aspergillus flavus and combined inoculation with Aspergillus flavus and Aspergillus ochraceus Journal of the Egyptian Public Health Association 78(5-6): 373-386Zapletal, O.; Piskac, A.; Malá, J.; Drazan, J. 1976: Isolation of a toxicogenic strain of the fungus, Aspergillus flavus, and characteristics of the produced aflatoxins Veterinarni Medicina 21(6): 321-330
Meshkov, N.V.; Bogoroditskaia, V.P. 1975: Study of the toxic effects of strains of Aspergillus flavus isolated from domestic grain products Voprosy Pitaniia 4: 59-62
Abubacker, M.N.; Ramanathan, R. 2003: Efficacy of Euphorbia splendens and Leonotis nepetaefolia on aflatoxin producing fungi Aspergillus flavus and Aspergillus parasiticus Indian Journal of Experimental Biology 41(12): 1473-1475
Tsyperovich, A.S.; Lysenkov, N.V. 1971: Peptidyl-peptide hydrolases of Aspergillus flavus Biokhimiia 36(5): 937-942
Irles, D.; Bonadona, A.; Pofelski, J.; Laramas, M.; Molina, L.; Lantuejoul, S.; Brenier-Pinchart, M.P.; Bagueta, J.P.; Barnoud, D. 2004: Aspergillus flavus endocarditis on a native valve Archives des Maladies du Coeur et des Vaisseaux 97(2): 172-175
Yokota, K.; Ebina, K.; Sakaguchi, O. 1980: Extracellular hemolytic toxin from Aspergillus flavus Nihon Saikingaku Zasshi. Japanese Journal of Bacteriology 35(6): 739-745
Naik, M.; Modi, V.V.; Patel, N.C. 1970: Studies on aflatoxin synthesis in Aspergillus flavus Indian Journal of Experimental Biology 8(4): 345-346
Strzelecki, E.L. 1972: Extraction and determination of Aspergillus flavus metabolites-aflatoxins from meat products Acta Microbiologica Polonica. Series B: Microbiologia Applicata 4(3): 155-164
Aleksandrowicz, J.; Adamek, T.; Laskownicka, Z.; Porebska, A.; Zemburowa, K. 1973: Studies on precipitating antibodies for Aspergillus flavus antigens in patients with proliferative diseases Materia Medica Polona. Polish Journal of Medicine and Pharmacy 5(4): 232-234
Adamek, T.; Aleksandrowicz, J.; Laskownicka, Z.; Porebska, A.; Zemburowa, K. 1971: Searching for antibodies against Aspergillus flavus antigens in patients with systemic prolifrative diseases Polski Tygodnik Lekarski 26(38): 1470-1471
Shevchenko, T.F.; Khlebutina, T.A.; Maĭgaranova, S.M. 1979: Effect of the toxic metabolites of the fungus, Aspergillus flavus, on the functional activity of the large intestine Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 10: 115-116
Whitehead, M.D.; Thirumalachar, M.J. 1971: Effect of aureofungin spray on the control of fungal diseases and Aspergillus flavus infestation in peanuts Hindustan Antibiotics Bulletin 13(3): 79-80
Wang, F.R.; Zhang, Z.D.; Jiao, B.Z.; Wang, Z.Y. 1981: Experimental studies of lung adenocarcinoma in mice induced by corn flour inoculated with Aspergillus flavus Zhonghua Zhong Liu Za Zhi 3(2): 91-93
Tendolkar, U.; Sharma, A.; Mathur, M.; Ranadive, N.; Sachdev, M. 2005: Epidural mass due to aspergillus flavus causing spinal cord compression--a case report and brief update Indian Journal of Medical Microbiology 23(3): 200-203
Biś, W.A. 1990: Immunological studies of the activity of Aspergillus flavus Link. I. Antigen analysis and evaluation of its chemical composition and toxicity Medycyna Doswiadczalna i Mikrobiologia 42(3-4): 143-148
De Lucca, A.J.; Boue, S.M.; Carter-Wientjes, C.; Bhatnagar, D. 2012: Volatile profiles and aflatoxin production by toxigenic and non-toxigenic isolates of Aspergillus flavus grown on sterile and non-sterile cracked corn Annals of Agricultural and Environmental Medicine: Aaem 19(1): 91-98
Yang, H.; Li, M.; Jiang, Y. 1997: Molecular cloning and sequence analysis of glycoprotein D gene of herpes simplex virus 2 strain Sav and wild strain isolated Zhonghua Yi Xue Za Zhi 77(2): 97-99
Hemingway, S.R.; Phillipson, J.D. 1972: N-oxides isolated during the alkaloid screening of Uncaria species Journal of Pharmacy and Pharmacology 24(Suppl): 169p-170
Kushida, N.; Atsumi, S.; Koyano, T.; Umezawa, K. 1997: Induction of flat morphology in K-ras-transformed fibroblasts by lycorine, an alkaloid isolated from the tropical plant Eucharis grandiflora Drugs under Experimental and Clinical Research 23(5-6): 151-155