Multiple cutaneous ecchymoses associated with the administration of bevacizumab
Trafalis, D.T.; Grivas, A.A.; Athanassiou, A.E.
Journal of BUON Official Journal of the Balkan Union of Oncology 13(4): 575-576
2008
ISSN/ISBN: 1107-0625 PMID: 19145684 Document Number: 620977
Nowadays, the introduction of combinational therapies with biological agents against advanced or resistant to chemotherapy tumors or for the treatment of cancer patients with organ failures becomes more and more attractive. The authors describe the case of a 60-year-old female patient with a multi-refractory to conventional cytotoxic therapy laryngeal cancer that was treated with cetuximab and bevacizumab combination therapy. Bevacizumab administration was associated with appearance of multiple cutaneous ecchymoses. This is a first-time reported adverse effect. Due to the recent launch of these agents and the limited experience of their use in clinical practice, their adverse effects and pharmacological toxicities are not well established and call for their detailed registration and reporting.