Human tumor growth in nude mice is associated with decreased plasma cysteine and homocysteine
Al-Awadi, F.; Yang, M.; Tan, Y.; Han, Q.; Li, S.; Hoffman, R.M.
Anticancer Research 28(5a): 2541-2544
2008
ISSN/ISBN: 0250-7005 PMID: 19035276 Document Number: 620270
The methionine cycle and its metabolites homocysteine and cysteine serve several important functions in cellular metabolism. Abnormalities in metabolism of the methionine cycle have been associated with cancer. We determined plasma levels of methionine, homocysteine and cysteine in nude mice implanted with human cancer cell lines (MDA-MB-435 breast, PC-3 prostate, HT29 colon, BX-PC3 pancreas) over a prolonged period of tumor growth.
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