Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection
Cheeramakara, C.; Khachonsaksumet, V.; Suthisai, N.; Nakosiri, W.; Songmuaeng, K.; Saenghirun, C.; Phienpicharn, D.; Nontprasert, A.
Southeast Asian Journal of Tropical Medicine and Public Health 39(2): 195-199
2008
ISSN/ISBN: 0125-1562 PMID: 18564701 Document Number: 620007
To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C-14-labelled arteether (20 mu Ci/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 +/- 34,134 dpm/cm(3)) than the liver (288,628.9 +/- 54,954 dpM/cm(3)) 4 hours post-injection. The main localization of labelled arteether was in the kidney cortex rather than the medulla (p < 0.05). However, the distribution of radioactivity was homogeneous in the liver. The terminal half-life of labelled arteether in the blood was 1.8 hours. The blood : kidney : liver ratio was 1 : 5 : 2. These findings show that labelled arteether was distributed quickly and localized in the cytoplasmic cortex of the kidney and homogeneously in the liver.