Effects of digoxin and corglycon on ion currents in neuronal membrane of snail (Lymnaea stagnalis)
Vislobokov, A.I.; Ignatov, I.D.; Mel'nikov, K.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 71(5): 19-24
2008
ISSN/ISBN: 0869-2092 PMID: 19093366 Document Number: 618469
The results of endocellular dialysis membrane potential monitoring show that cardiac glycosides digoxin and corglycon in concentration from 10(-12) to 10(-6) M influence the sodium, calcium and potassium ion currents in isolated snail (Lymnaea stagnalis) neurons in reversible and slightly dose-dependent manner. In low concentration (10(-12) - 10(-8) M) both substances increased all ionic currents by up to 5%, while in higher concentrations both drugs led to the suppression of ion currents. The most pronounced decrease (up to 26% relative to control) was observed for sodium ion current under the action of digoxin in a concentration of 10(-6) M. The process of slow potassium currents inactivation was accelerated by corglycon in a concentration of 10(-6) M. Digoxin caused a shift in the current - voltage curve maximum by 5 - 10 mV to the right on the potential axis. Generally, digoxin in comparison to corglycon produced less activating and more suppressing effect on the membrane ion currents studied.