Properties of membrane ionic currents in pituitary clone cells
Dufy, B.; Barker, J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 177(2): 166-174
1983
ISSN/ISBN: 0037-9026 PMID: 6224537 Document Number: 211902
Membrane ionic currents of the GH3 pituitary cell line have been studied using voltage clamp techniques. The inward current is completely blocked by cobalt (Co2+) ions and appeared to be carried by calcium ions. Three outward currents can be differentiated on the ground of kinetics and pharmacological studies: a transient current blocked by 4-aminopyridine (4 AP) and two delayed outward current which are voltage dependent. One is blocked by tetraethylammonium (TEA); the second is blocked by Co2+ and represents a calcium-activated potassium conductance.