Ionic currents in ventricular myocytes isolated from the heart of a patient with idiopathic cardiomyopathy
Nánási, P.P.; Varró, A.; Lathrop, D.A.
Cardioscience 3(2): 85-89
1992
ISSN/ISBN: 1015-5007 PMID: 1379481 Document Number: 395287
Whole-cell configuration of the patch-clamp technique was applied to record ionic currents from human ventricular myocytes isolated from a cardiac transplant patient with idiopathic cardiomyopathy. Inward calcium current, transient outward current, and inward rectifier potassium current were recorded, while no discernible delayed rectifier potassium current was observed. Thus the currents that underlie electrical activity in human ventricular myocytes appear to resemble those reported earlier in canine and rabbit ventricular myocytes.