Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort
Lubiński, J.; Tarnowska, C.ła.; Jaworowska, E.; Byrski, T.; Jakubowska, A.; Górski, B.; Bień, S.ła.; Sygut, J.; Góźdź, S.ła.; Siołek, M.; Sulikowski, M.ła.; Lubiński, J.
Anticancer Research 28(5b): 3011-3013
2008
ISSN/ISBN: 0250-7005 PMID: 19031948 Document Number: 618348
The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations. Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland. BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland. Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours. Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.