Pharmacokinetics of dihydroartemisinin in a murine malaria model
Batty, K.T.; Gibbons, P.L.; Davis, T.M.E.; Ilett, K.F.
American Journal of Tropical Medicine and Hygiene 78(4): 641-642
2008
ISSN/ISBN: 0002-9637 PMID: 18385362 Document Number: 618346
Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls.
Document emailed within 1 workday
Related Documents
Thuy, L.Thi.Diem.; Hung, L.Ngoc.; Hung, N.Canh.; Na-Bangchang, K. 2007: Pharmacokinetics of mefloquine with dihydroartemisinin as 2-day regimens in patients with uncomplicated falciparum malaria Southeast Asian Journal of Tropical Medicine and Public Health 38(2): 205-212Xu, C.; Ding, Y.; Qi, Z. 1997: Efficacy of dihydroartemisinin in treatment of 37 malaria cases Zhonghua Nei Ke Za Zhi 36(3): 187-189
Onyamboko, M.A.; Meshnick, S.R.; Fleckenstein, L.; Koch, M.A.; Atibu, J.; Lokomba, V.; Douoguih, M.; Hemingway-Foday, J.; Wesche, D.; Ryder, R.W.; Bose, C.; Wright, L.L.; Tshefu, A.K.; Capparelli, E.V. 2011: Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC Malaria Journal 10: 49
Rijken, M.J.; McGready, R.; Boel, M.E.; Barends, M.; Proux, S.; Pimanpanarak, M.; Singhasivanon, P.; Nosten, Fçois. 2008: Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report American Journal of Tropical Medicine and Hygiene 78(4): 543-545
Katrak, S.; Gasasira, A.; Arinaitwe, E.; Kakuru, A.; Wanzira, H.; Bigira, V.; Sandison, T.G.; Homsy, J.; Tappero, J.W.; Kamya, M.R.; Dorsey, G. 2009: Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children Malaria Journal 8: 272
Woods, M.L.; Mayer, J.; Evans, T.G.; Hibbs, J.B. 1994: Antiparasitic effects of nitric oxide in an in vitro murine model of Chlamydia trachomatis infection and an in vivo murine model of Leishmania major infection Immunology Series 60: 179-195
Wilairatna, P.; Krudsood, S.; Silachamroon, U.; Singhasivanon, P.; Vannaphan, S.; Faithong, S.; Klabprasit, M.; Bangchang, S.N.; Olliaro, P.; Looareesuwan, S. 2000: Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand American Journal of Tropical Medicine and Hygiene 63(5-6): 290-294
Pedercini, M.; Movilla Blanco, S.; Kopainsky, B. 2011: Application of the malaria management model to the analysis of costs and benefits of DDT versus non-DDT malaria control PLOS one 6(11): E27771
Jayawardena, A.N.; Targett, G.A.; Davies, A.J.; Leuchars, E.; Carter, R. 1975: Changes in PHA and LPS responsiveness in murine malaria Transactions of the Royal Society of Tropical Medicine and Hygiene 69(4): 426
Dorr, R.T.; Liddil, J.D.; Von Hoff, D.D.; Soble, M.; Osborne, C.K. 1989: Antitumor activity and murine pharmacokinetics of parenteral acronycine Cancer Research 49(2): 340-344
Feng, Z.; Wu, Z.F.; Wang, C.Y.; Jiang, N.X. 1987: Pharmacokinetics of pyronaridine in malaria patients Zhongguo Yao Li Xue Bao 8(6): 543-546
White, N.J. 1987: The pharmacokinetics of quinine and quinidine in malaria Acta Leidensia 55: 65-76
Curfs, J.H.; Schetters, T.P.; Hermsen, C.C.; Jerusalem, C.R.; van Zon, A.A.; Eling, W.M. 1989: Immunological aspects of cerebral lesions in murine malaria Clinical and Experimental Immunology 75(1): 136-140
Miller, K.L.; Schooley, J.C.; Smith, K.L.; Kullgren, B.; Mahlmann, L.J.; Silverman, P.H. 1989: Inhibition of erythropoiesis by a soluble factor in murine malaria Experimental Hematology 17(4): 379-385
Lee, S.J.; McGready, R.; Fernandez, C.; Stepniewska, K.; Paw, M.K.; Viladpai-nguen, S.J.; Thwai, K.L.; Villegas, L.; Singhasivanon, P.; Greenwood, B.M.; White, N.J.; Nosten, F.ço. 2008: Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria European Journal of Clinical Pharmacology 64(10): 987-992
Horspool, K.R.; Quarterman, C.P.; Slack, J.A.; Gescher, A.; Stevens, M.F.; Lunt, E. 1989: Metabolism and murine pharmacokinetics of the 8-(N,N-dimethylcarboxamide) analogue of the experimental antitumor drug mitozolomide (NSC353451) Cancer Research 49(18): 5023-5026
Blakey, D.C.; Skilleter, D.N.; Price, R.J.; Watson, G.J.; Hart, L.I.; Newell, D.R.; Thorpe, P.E. 1988: Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells Cancer Research 48(24 Part 1): 7072-7078
Shear, H.L.; Srinivasan, R.; Nolan, T.; Ng, C. 1989: Role of IFN-gamma in lethal and nonlethal malaria in susceptible and resistant murine hosts Journal of Immunology 143(6): 2038-2044
Grau, G.E.; Piguet, P.F.; Engers, H.D.; Louis, J.A.; Vassalli, P.; Lambert, P.H. 1986: L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria Journal of Immunology 137(7): 2348-2354
Owhashi, M.; Kirai, N.; Asami, M. 1996: Temporary appearance of a circulating granulocyte-macrophage colony-stimulating factor in lethal murine malaria Southeast Asian Journal of Tropical Medicine and Public Health 27(3): 530-534