Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats
Duan, H.-G.; Wei, Y.-H.; Li, B.-X.; Zhang, D.-M.; Zhang, J.-W.; Wu, X.-A.
Zhongguo Zhong Yao Za Zhi 33(18): 2133-2135; 2139
2008
ISSN/ISBN: 1001-5302 PMID: 19160803 Document Number: 617828
To study effects of Yuquan pills on the pharmacokinetics process of metformin hydrochloride in diabetic rats. After administration Yuquan pills 7 day to the diabetic rats, the metformin hydrochloride was orally administrated, then the blood samples were collected at different time. The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated. The pharmacokinetic parameter Cmax of the controlling group and the testing group were respectively, 18.95, 21.76 mg x L(-1); t1/2 were 1,069.8, 1,767.4 min, respectively; CL/F were 0.013, 0.008 L x min(-1) x kg(-1); AUC were 10,042.1, 10,712.2 mg z L(-1) x min(-1) respectively. The pharmacokinetics process of metformin hydrochloride in diabetic rats fits one-compartment model. Yuquan pills has a significant effect on the pharmacokinetics of metformin hydrochloride in diabetic rats.