Expression of OCTN2 mRNA in the human epididymis and its significance
Gong, D.-M.; Li, Z.; Zhu, X.-B.; Liu, Y.-L.; Cao, X.-R.; Liu, Y.; Wang, Y.-X.
Zhonghua Nan Ke Xue 14(3): 242-244
2008
ISSN/ISBN: 1009-3591 PMID: 18488339 Document Number: 617573
To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception. We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR. OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis. The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.