Animal models of tissue ischemia to evaluate the importance of oxygen in the wound healing environment
Myers, W.T.; Gould, L.J.
Wounds a Compendium of Clinical Research and Practice 20(1): 9-17
2008
ISSN/ISBN: 1044-7946 PMID: 25942756 Document Number: 616977
Localized tissue ischemia is a key factor in the development and poor prognosis of chronic wounds. The wide variety of wounds that occur in humans along with multiple comorbidities has precluded the ability to truly define, understand, and optimize treatment(s) for chronic wounds. As these difficult wounds appear to be uniquely human, investigators have had to create models of impaired wound healing for experimental manipulation. The ideal animal model would be relatively inexpensive, reproducible, and adaptable so that laboratories could use it to mimic the human condition. This article will review the current understanding of the effect of ischemia on wound healing and examine the features of currently available animal models that simulate ischemic wounds.