Serotonin syndrome caused by olanzapine and clomipramine
Verre, M.; Bossio, F.; Mammone, A.; Piccirillo, M.; Tancioni, F.; Tortorella, V.; Varano, M.
Minerva Anestesiologica 74(1-2): 41-45
2008
ISSN/ISBN: 0375-9393 PMID: 18004234 Document Number: 616360
We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient's condition improved.