Psychotic syndrome after withdrawal of cyproheptadine: remission with olanzapine
De Lucas Taracena, M.T.; Alcaina Prosper, T.; Huélamo Ortega, M.J.
Actas Espanolas de Psiquiatria 28(4): 270-272
2000
ISSN/ISBN: 1139-9287 PMID: 11116800 Document Number: 523369
Cyproheptadine is a drug with direct antimuscarinic, antihistaminic (H1) and antiseronergic (5HT2) effects. In spite of its use as an orexigenic agent in normal or anorectic subjects, little is known about its effect in affective, anxiety or psychotic disorders. We present the case of a 14-year patient beginning with a psychotic syndrome after the sudden withdrawal cyproheptadine, achieving a total control of the symptoms with olanzapine at low dose, besides a good family, school and social adaptation.