Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin
Michalska, M.; Pajak, W.; Kołodziejska, J.; Lazarenkow, A.; Nawrot-Modranka, J.
Acta Biochimica Polonica 55(3): 613-617
2008
ISSN/ISBN: 0001-527X PMID: 18800174 Document Number: 616305
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.