Progress in the study of pH and temperature sensitive biodegradable block copolymers
Hao, T-Na.; Qiao, M-Xi.; Li, Z.; Chen, D-Wei.
Yao Xue Xue Bao 43(2): 123-127
2008
ISSN/ISBN: 0513-4870 PMID: 18507336 Document Number: 615410
pH and temperature sensitive biodegradable block copolymers are some macromolecules connected by biodegradable materials and pH sensitive monomers according to a certain sequence, or biodegradable polyesters polymerized themselves. On the basis of pertinent documents, the development of pH and temperature sensitive biodegradable block copolymers was introduced, involving their mechanism of action and potential application. PH and temperature sensitive biodegradable block copolymers could control the drug release rate freely, avoiding burst effect. Besides, the biocompatibility of these biodegradable materials is also excellent. So the use of pH and temperature sensitive biodegradable block copolymers as biodegradable drug delivery devices has attracted considerable interest in the intelligent drug delivery system.