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Structural organization of DNA complexes with proteins HMGB1 and HMGB1- (A+B)

Polianichko, A.M.; Leonenko, Z.V.; Kramb, D.; Vieser, G.; Vorob'ev, V.I.; Chikhirzhina, E.V.

Biofizika 53(3): 407-416

2008

ISSN/ISBN: 0006-3029
PMID: 18634312
Document Number: 615333
The interaction between DNA and the nonhistone proteins HMGB1 and HMGB1-(A+B) has been studied using circular dichroism and scanning force microscopy. The recombinant protein HMGB1-(A+B) has no negatively charged C-terminal domain characteristic for HMGB1. Our earlier suggestion about the structural interaction of tandem HMGB1-domains of the recombinant protein with DNA was confirmed. It was shown that the C-terminal part modulates the interactions of HMGB1-domains with DNA. Without the C-terminal sequence, the HMGB1-(A+B) protein forms DNA-protein complexes with the ordered supramolecular structure.

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