The role of a mitochondrial palmitate/Ca (2+) -activated pore in palmitate-induced apoptosis
Belosludtsev, K.N.; Belosludtseva, N.V.; Mironova, G.D.
Biofizika 53(6): 967-971
2008
ISSN/ISBN: 0006-3029 PMID: 19137679 Document Number: 615250
Evidence for the possible involvement of the mitochondrial cyclosporin A-insensitive palmitate/Ca(2+)-activated pore in the apoptotic process is presented. It has been established that the opening of palmitate/Ca(2+)-activated pore results in high-amplitude swelling of mitochondria and the release of apoptosis-induced factor from organelles. These processes are accompanied by a transitory small decrease of membrane potential, which recovers in 1 min. The possible role of palmitate/Ca(2+)-activated pore in the induction of palmitate-activated apoptosis is discussed.