Matrix metalloproteinase-9 (MMP-9) immunoreactive protein in urinary bladder cancer: a marker of favorable prognosis
Vasala, K.; Pääkko, P.; Turpeenniemi-Hujanen, T.
Anticancer Research 28(3b): 1757-1761
2008
ISSN/ISBN: 0250-7005 PMID: 18630455 Document Number: 615229
Backround: The purpose of this study was to explore whether changes in matrix metalloproteinase-9 (MMP-9) are involved in the Progression of urinary bladder cancer and whether they have any prognostic value. Patients and Methods: Overexpression of MMP-9 was evaluated in the primary tumor of 87 urinary bladder cancer cases with immunohistochemical staining. Results: Of the urinary bladder carcinomas, 38% showed an overexpression (>25%) of MMP-9 immunoreactive protein. Increased positivity for MMP-9 correlated with favorable overall survival of the urinary bladder cancer patients. The 5-year overall survival and relapse-free survival was 68% and 36% in patients showing high MMP-9 expression and 48% and 19% inpatients with low (<25%) or negative MMP-9 expression (p=0.006, p=0.08, respectively). In multivariate analysis, MMP-9 overexpression seems to retain its independent prognostic value. Conclusion: This study shows that MMP-9 expression in urinary bladder carcinoma is associated with better prognosis.