Clinical significance of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in peripheral blood of patients with gastric carcinoma
Yoshikawa, T.; Suzuki, K.; Kobayashi, O.; Sairenji, M.; Motohashi, H.; Yanoma, S.; Noguchi, Y.; Tsuburaya, A.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 25(9): 1461-1464
1998
ISSN/ISBN: 0385-0684 PMID: 9703854 Document Number: 485162
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in peripheral blood were measured in 54 patients with gastric carcinoma; 46 were primary and 8 were recurrent cases. There were no significant associations between MMP-9 concentrations and clinicopathological factors. TIMP-1 levels were significantly increased in advanced and recurrent cases, and in cases with peritoneal dissemination and lymph node metastasis, suggesting that TIMP-1 concentration in the peripheral blood could be a new tumor marker for the recurrence of gastric carcinoma.