Effect of perindopril on cognitive functions in young and middle aged patients with hypertensive disease
Smakotina, S.A.; Trubnikova, O.A.; Anan'ko, I.A.; Barbarash, O.L.
Kardiologiia 48(9): 28-33
2008
ISSN/ISBN: 0022-9040 PMID: 18991817 Document Number: 615211
We studied 40 men aged 26 - 59 years (mean age 49.0 +/- 1.9 years) with hypertensive disease (HD) and found that therapy based on the use of angiotensin converting enzyme inhibitor perindopril in young and middle aged patients with stage I and II HD appeared to be not only one of effective methods of correction of elevated arterial pressure (AP) but also of associated with it cognitive abnormalities. Effect of therapy was determined by achievement of target AP values and was more pronounced in patients older than 44 years. Favorable effects of perindopril in relation to parameters of cognitive functions in patients with HD allows to rate perindopril not only as effective and safe hypotensive preparation but as remedy exerting cerebroprotective effect.