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Influence of cardiopulmonary bypass on cognitive functions in patients with ischemic heart disease

Buziashvili, I.I.; Ambat'ello, S.G.; Aleksakhina, I.A.; Pashchenkov, M.V.

Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 105(1): 30-35

2005

ISSN/ISBN: 1997-7298
PMID: 15704480
Document Number: 584605
Forty patients with ischemic heart disease subjected to coronary artery bypass graft surgery (CARGS) have been studied in conditions of cardiopulmonary bypass. All the patients underwent neuropsychological testing and enzyme immunoassay of chemokines (IL-8, IP-10, MCP-1, MCP-3, MIP-1 beta, SDF-1 alpha) and cytokines (TNF-alpha and IL-10). The study aimed at evaluation of the presence and severity of cognitive deficit developing after the surgery in conditions of cardiopulmonary bypass as well as of intrasurgery effect of tracilol on its expression. On day 9 after CARGS, there was an impairment of attention, audio-speech and memory and dynamic praxis. Tracilol exerted a pronounced neuroprotective action by inhibiting systemic inflammation response. Patients on intrasurgery treatment with tracilol did not demonstrate clinically significant cognitive deficit in the early postoperative period.

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