A simple and rapid flow-injection chemiluminescence method for the determination of noscapine with Ru (phen) 3 (2+) -Ce (IV) system
Rezaei, B.; Mokhtari, A.; Khayamian, T.
Annali di Chimica 97(8): 605-614
2007
ISSN/ISBN: 0003-4592 PMID: 17899875 Document Number: 614491
A new flow injection chemilulminescence (CL) system was used for the determination of noscapine. This technique is based on the reduction effect of noscapine on the Ru(phen)(3)(3+), which is produced by reaction between Ru(phen)(3)(2+) and acidic Ce(IV) solutions, and this rapid reduction produces strong CL. Calibration plots were linear over the ran-e of 3.0 x 10(-7) -2.0 x 10(-6) mol L-1 and 2.0 x 10(-6) -2.0 x 10(-4) mol L-1. The CL intensity was so high, that it is able to produce a detection limit of 6.6 x 10(-8) M noscapine (3 sigma). The relative standard deviation of 2.0 x 10(-6) M noscapine was 1.0% (n=10). The proposed method was successfully applied for the flow injection determination of noscapine in cough and Tonin syrup samples. The results of real sample analyses show good recovery percentages (97.3-102.4%). The minimum sampling rate was 100 samples per hour.