The relationship between adaptation to hypoxia and the monoaminergic systems of the central nervous system
Mamalyga, M.L.
Aviakosmicheskaia i Ekologicheskaia Meditsina 41(4): 60-63
2007
ISSN/ISBN: 0233-528X PMID: 18035716 Document Number: 614480
The role of CNV monoaminergic systems (MAES) in development of residual adaptation was studies in Wistar rats with high and low resistance to hypoxia and varying adaptive potential. Adaptability to hypoxia was found to depend on initial resistance to the factor. Mobilization of the adaptive potential was reflective of specifics of the MAES mechanisms. In well-adapted animals the MA concentration was typically high with the desamination products either increased or decreased depending on individual sensitivity to hypoxia. In poorly adapted rats MA synthesis by the stress-suppressing systems was lowered which prevented the humoral effects resulting in the development of residual structural and functional adaptation.