Sodium oxybutyrate normalizes the central nervous system functions in the progeny of rats subjected to hypobaric hypoxia during pregnancy
Trofimov, S.S.; Ostrovskaia, R.U.; Smol'nikova, N.M.; Kravchenko, E.V.; Kutepova, O.A.; Bondarenko, N.A.; Nerobkova, L.N.; Nemova, E.P.; Voronina, T.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 56(6): 8-11
1993
ISSN/ISBN: 0869-2092 PMID: 8111305 Document Number: 414252
Two-hour hypobaric hypoxia of rats on day 15 of their pregnancy led to a reduction in weight gain of pups within 20 days after birth, disturbed memory in active and passive paradigms, changed adaptive behavior in the extrapolatory water avoidance test, and impaired sleep in adult animals. Postnatal treatment with sodium hydroxybutyrate given in a dose of 50 mg/kg/day on days 8 to 20 of life normalized mnestic functions of the brain, the process of falling asleep, and physical development which had been impaired by intrauterine hypoxia.