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Effects of folate on proliferation and differentiation of neural stem cells in vitro

Ji, C.; Huang, G.; Zhang, W.; Su, X.

Wei Sheng Yan Jiu 36(5): 578-580

2007

ISSN/ISBN: 1000-8020
PMID: 18095571
Document Number: 614110
To explore the protective effect of folic acid on proliferation and differentiation of neural stem cells in vitro. On the 14th day of gestation, NSCs were obtained. MTT method was used to detect the proliferation of NSCs cultured with folic acid of different concentrations and time. After 6 days, the NSCs purified were placed into culture dishes of fetus bovine serum. On the seventh day of differentiation, double-tabeling immunofluorescence with antibody Nestin and BrdU was taken to calculate the number of NSCs by 8 fields of vision chosen randomly . Comparing to control group, NSCs of folate group was increase and better, and significantly (P < 0.05). Folic acid may suppress proliferation and differentiation of NSCs efficiently.

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