Effect of glucosamine sulfate on the analgesic and ulcerogenic activity of ketoprofen
Violin, B.V.; Kompantsev, D.V.; Pogorelyĭ, V.E.; Makarova, L.M.; Kompantseva, E.V.; Leonova, V.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 70(3): 53-55
2007
ISSN/ISBN: 0869-2092 PMID: 17650636 Document Number: 612203
The effect of glucosamine sulfate on the analgesic properties and ulcerogenic action of ketoprofen has been experimentally studied in the course of drug adminstration in laboratory animals in comparison to the ketoprofen monotherapy. An analysis of the results shows that the combined application of glucosamine sulfate with ketoprofen produces a twofold increase in the analgesic activity of ketoprofen and decreases the drug-induced damage of the stomach mucous membrane. These effects are especially pronounced for the following ratio of components: ketoprofen, 16 or 24 mg/kg; glucosamine sulfate, 125 mg/kg.