Effect of vaccination against pneumococcal infection and influenza in children with asthma
Andreeva, N.P.; Petrova, T.I.; Golubtsova, O.I.; Kozhevnikova, S.L.; Kostinov, M.P.; Karpocheva, S.V.; Magarshak, O.O.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2007(3): 74-77
2007
ISSN/ISBN: 0372-9311 PMID: 17672137 Document Number: 611388
Assessment of clinical course of asthma and IgG response in children with asthma immunized with pneumococcal polysaccharide vaccine (Pneumo 23) and influenza vaccine (Vaxigrip). 78 children aged 4 - 17 years old were allocated to two groups. Children from the 1(st) group were immunized against pneumococcal infection and influenza; children from 2(nd) group were immunized against pneumococcal infection only. Rateof asthma exacerbations in the 1(st) group of children decreased by 1.7 times compared with the period before vaccination, whereas the same rate in the 2(nd) group of children decreased by 1.5 times. It was accompanied by the increase of IgG level to antigens of pneumococcal vaccine in blood, which was observed in both groups. Vaccination did not result in increase of IgE levels. Immunization of children with asthma against pneumococcal infection with polysaccharide vaccine or combined immunization against pneumococcal infection and influenza reduced rate of asthma exacerbations and led to formation of immunity to vaccine strains of Streptococcus pneumoniae. Vaccination did not lead to sensitization of children.