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Influenza vaccination of children with hemophilia

Klukowska, A.; Brydak, L.; Rokicka-Milewska, R.; Gosk, B.; Wielopolska, M.; Adamowicz-Salach, A.; Rudnicka, H.; Regnery, H.; Cox, N.

Acta Haematologica Polonica 26(3): 305-310

1995

ISSN/ISBN: 0001-5814
PMID: 8525777
Document Number: 447667
51 haemophilic children aged from 7 to 16 years was vaccinated against influenza in Paediatric Department of Haematology and Oncology in November and December of 1993. Each dose of subunit vaccine manufactured by Wyeth-USA, contained 15 micrograms of each haemagglutinin strains as recommended for the season. The antibody level was studied before and after influenza vaccination in vaccinated and control group as well. 5-time rise of geometric mean antibody titre was found for H1N1 and H3N2 antigens after vaccination of the children group. Slightly lower, 2.7-time rise of GMT was showed for HB haemagglutinin of influenza virus. There was no significant rise of GMT for any among three studied virus haemagglutinin.

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