Parathyroid and bone. Indication for parathyroidectomy in primary hyperparathyroidisms
Imanishi, Y.
Clinical Calcium 17(12): 1895-1900
2007
ISSN/ISBN: 0917-5857 PMID: 18057666 Document Number: 610843
Primary hyperparathyroidism is a disease in which somatic chromosomal defects such as activations of oncogenes or inactivations of tumor suppressor genes enhance chromosomal parathyroid cell growth. Decreased calcium-sensing receptor causes oversecretion of PTH from abnormal parathyroid cells. Oversecreted PTH enhances bone turnover and finally exhibits bone fragility. In this review, the indications of parathyroidectomy and the effects of parathyroidectomy on bone in primary hyperparathyroidism are discussed.
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