Parathyroid and bone. the mechanism of anabolic function of parathyroid hormone on bone
Ogata, N.; Kawaguchi, H.
Clinical Calcium 17(12): 1843-1849
2007
ISSN/ISBN: 0917-5857 PMID: 18057659 Document Number: 612795
Parathyroid hormone (PTH) has been applied to postmenopausal women and several studies revealed that intermittent PTH treatment significantly increases lumbar bone mineral density and reduces fracture risk. However, the mechanism of PTH anabolic function on bone is not fully understood yet. PTH receptors (PPR) are expressed in osteoblasts and PPR stimulates multiple intracellular signal pathways, including those mediated by cAMP-PKA signaling pathway and PLC-PKC signaling pathway. Several studies demonstrate that the PKA signaling through G-proteins in osteoblasts play important roles in regulating gene expression and osteogenesis by PTH.