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Electrophysiological changes in patients with early stages of Alzheimer's disease

Krasodomska, K.; Lubiński, W.; Potemkowski, A.; Honczarenko, K.; Gołab-Janowska, M.; Ratajczak, M.; Szych, Z.

Annales Academiae Medicae Stetinensis 53(Suppl 1): 49-57; Discussion 57

2007

ISSN/ISBN: 1427-440X
PMID: 19425480
Document Number: 610586
An evaluation of retinal and optic nerve bioelectrical function in patients with early stages of Alzheimer's disease. 30 eyes of 15 patients in the early stage of Alzheimer's disease with normal eye fundus appearance were analysed. Electrophysiological tests of the retina and optic nerve (FVEP, PVEP, PERG, ERG) were performed according to ISCEV standards. The dysfunction of the retina and optic nerve was observed. The most common abnormalities were noted in PVEP test (latency increase of P100-wave--36.7% eyes) and in PERG test (latency increase of P50-wave--33.3% eyes). In patients with early stage of Alzheimer's disease there is a dysfunction of the retina and optic nerve, which can be detected by electrophysiological tests, even in patients with normal eye fundus.

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