Apolipoprotein e genotypes in sporadic early and late-onset Alzheimer's disease
Kowalska, A.; Florczak, J.; Pruchnik-Wolińska, D.; Kraszewski, A.; Wender, M.
Archivum Immunologiae et Therapiae Experimentalis 46(3): 177-181
1998
ISSN/ISBN: 0004-069X PMID: 9704150 Document Number: 485446
Recent data have demonstrated that presence of apolipoprotein E (APOE) epsilon *4 allele is a major risk factor of Alzheimer's disease (AD). We determined the APOE genotypes in 64 patients with sporadic probable AD and 43 non-demented aged controls selected from Poznań region and the western part of Poland using the polymerase chain reaction (PCR) followed by the restriction fragment length polymorphism (RFLP) analysis. We confirmed a strong correlation of the APOE epsilon *4 allele with sporadic late-onset AD. In contrast to many previous reports we did not found an association between the APOE epsilon *4 allele and sporadic early-onset AD.