Hepatitis B virus genotypes: a retrospective survey in Southwestern France, 1999-2004
Trimoulet, P.; Boutonnet, M.; Winnock, M.; Faure, M.; Loko, M-Arthur.; De Lédinghen, V.; Bernard, P-Henri.; Castéra, L.; Foucher, J.; Dupon, M.; Ragnaud, J-Marie.; Lafon, M-Edith.; Couzigou, P.; Dabis, Fçois.; Fleury, Hé.; Neau, D.
Gastroenterologie clinique et biologique 31(12): 1088-1094
2007
ISSN/ISBN: 0399-8320 PMID: 18176363 Document Number: 609365
To determine the prevalence of HBV genotypes in Southwestern France and the association between HBV genotypes and patients characteristics. 194 HBsAg-positive patients (median age: 45 yrs, range: 7-77, male: 78%) followed in Bordeaux Hospital in 1999-2004 were included. HBV genotype, pre-core (PC) and core promoter (CP) mutations were determined by sequencing. Genotype distribution was A 51%, B 6.7%, C 5.7%, D 26.3%, E 7.7%, F 0.5%, G 2.1%. Among the 146 patients documented, 71.2% were Caucasians, 15.8% Africans, 13.0% Asians. Fifty-seven patients (36%) were HIV-infected. Eighty-two (42.3%) patients were HBeAg-positive. Genotype A was almost exclusively carried by Caucasians (96%), Africans were most frequent among genotype E (82%), and Asians were most prevalent among genotypes B and C (82% and 80%, respectively). Genotype A was associated with a higher prevalence of HBeAg than genotype D (53% versus 35.3%, P=0.03). PC variant was detected in 35% and CP variant in 43% of patients. PC variant was uncommon in genotype A patients (7.3%). Distribution of HBV genotypes differs according to ethnic origin, genotypes A and D being the most frequently found. Genotype A was more frequently associated with HBeAg-positivity and genotype D with HBeAg-negativity.