Update on Kaposi's sarcoma
Morand, J.J.; Lightburn, E.; Simon, F.; Patte, J.H.
Medecine Tropicale Revue du Corps de Sante Colonial 67(2): 123-130
2007
ISSN/ISBN: 0025-682X PMID: 17691428 Document Number: 608796
Kaposi's sarcoma (KS) is a mesenchymal tumor involving blood and lymphatic vessels and induced by viral growth factors (HHV8-IL6). This article reviews the epidemiology, pathogenesis, clinical spectrum (classic KS, iatrogenic immunosuppressive KS, endemic African KS, and AIDS-KS), histological features, staging criteria and treatment of KS. Unlike industrialized countries that have benefited from widespread use of highly active antiretroviral therapy (HAART), developing countries continue to have a high incidence of AIDS-KS. Future therapeutic targets for KS are enhancement of immune function and treatment with angiogenesis inhibitors