Pre-Kaposi's sarcoma: an expansion of the spectrum of Kaposi's sarcoma lesions
Simonart, T.; Dobbeleer, G.D.; Peny, M.; Fayt, I.; Parent, D.; Vooren, J.; Noel, J.
European Journal of Dermatology Ejd 9(6): 480-482
1999
ISSN/ISBN: 1167-1122 PMID: 10491508 Document Number: 507160
We report on a lymphoedematous form of classic Kaposi's sarcoma (KS) in which characteristic purplish lesions were surrounded by atypical oedematous, flesh-coloured papules. Histological examination of these papular lesions revealed a proliferation of grouped, rather thick-walled capillaries with inflammatory infiltrates. Hot-start PCR amplification with KS 330-233 primer sequences demonstrated the presence of human herpesvirus 8 (HHV-8) sequences. In addition, cells isolated from these oedematous papules showed morphological and immunohistochemical features similar to those reported for KS-derived spindle cells. As a whole, these results suggest that these oedematous papular lesions represent pre-KS lesions and may expand the clinico-pathological spectrum of KS. The role of oedema in their induction is discussed.