Suppression of WIFI transcript and protein in non-small cell lung carcinomas
Korobko, E.V.; Kalinichenko, S.V.; Shepelev, M.V.; Zborovskaia, I.B.; Allakhverdiev, A.K.; Zinov'eva, M.V.; Vinogradova, T.V.; Sverdlov, E.D.; Korobko, I.V.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2007(2): 13-18
2007
ISSN/ISBN: 0208-0613 PMID: 17598452 Document Number: 608190
Changes in WIF1 expression, an extracellular inhibitor of Wnt pathway, in non-small cell lung carcinomas were analyzed. Frequent (67% cases) suppression of WIF1 transcript in non-small cell lung carcinomas were found. Our results, together with previously published data, suggest that inhibition of WIFI expression often occurs in squamous cell carcinomas and is less typical of adenocarcinomas. It was also found that a decrease in the WIFI transcript in tumors is parallel to concomitant Suppression of the WIFI protein level. Our results provide further evidence that the WIFI suppression is a frequent event in the lung carcinogenesis, which might lead to disregulation of Wnt signaling pathway and contribute to tumor progression.