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Bcl-2 protein expression correlates with nodal status in non small cell lung cancer

Groeger, A.M.; Caputi, M.; Esposito, V.; De Luca, A.; Salat, A.; Murabito, M.; Giordano, G.G.; Baldi, F.; Giordano, A.; Wolner, E.

Anticancer Research 19(1b): 821-824

1999

ISSN/ISBN: 0250-7005
PMID: 10216499
Document Number: 508916
We investigated the immunohistochemical expression of bcl-2 in 55 non small cell lung cancer patients in order to understand if the altered expression of this gene is involved in the development of this kind of neoplasm. Our results showed bcl-2 immunopositivity to be a frequent event in non small cell lung cancer (54.5%) with a higher expression in squamous carcinomas compared to adenocarcinomas (p = .04). In addition, we found a positive correlation between bcl-2 expression levels and nodal status (p < .003). We suggest that bcl-2 immunostaining could be considered as marker of loco-regional invasivity.

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