Effects of shengmai for injection on cardiogenic shock
Ding, X.-F.; Chen, G.; Liu, Y.-L.
Zhongguo Zhong Yao Za Zhi 32(21): 2298-2305
2007
ISSN/ISBN: 1001-5302 PMID: 18309678 Document Number: 608176
To study the protective effects and the possible mechanism of shengmai for injection(SM) against the experimental acute cardiogenic shock. The experimental acute cardiogenic shock model was established by ligating the anterior descending cornonary in dogs. The effects of SM on cardiogenic shock were investigated by measuring the hemodynamics parameter, the activity of LDH, CK, SOD and the contents of MDA in blood serum. In the dogs treated with SM, the mean arterial pressure (MAP), heart rate (HR), left ventricular pressure (LVP), the maximum of its first derivative (+/- dp/dtmax), the cardiac output (CO) and the cardiac index (CI) were increased significantly. The left ventricular end diastolic pressure (LVEDP) and the peripheral vascular resistance (TPVR) were decreased significantly, the myocardial infarct size was redused observely. In addition, the activity of LDH, CK and the contents of MDA in serum were decreased significantly, however the activity of SOD was increased observely. The results indicate that SM has the protective effects on cardiogenic shock.