Change of dehydroepiandrosterone in serum of 6 - 18 year-old twin girls in Qingdao City
Li, H.; Ji, C.
Wei Sheng Yan Jiu 36(1): 41-42
2007
ISSN/ISBN: 1000-8020 PMID: 17424846 Document Number: 608086
To explore the change of serum dehydroepiandrosterone (DHEAS) concentrations throughout the puberty of girls and estimate the effects of genetic and environmental factors on serum DHEAS. The study population consists of 360 girls aged 6 to 18 years:132 pairs monozygotic twins and 48 pairs dizygotic twins, who were all from Qingdao city, Shan-dong province. Anthropometric measurement and pubertal development stage were determined by Tanner standard, fasting serum DHEAS contents were assayed by RIA. Serum DHEAS concentrations increased from Tanner I to IV and decreased later, heritability of pubertal girl's serum DHEAS was 0.65. The heritability of 3 different pubertal stages (pre-thelarche, post-thelarche and pre-menarche, and post-menarche) were 0.92, 0.73 and 0.67 respectively. Serum DHEAS concentrations of pubertal girls could be mainly influenced by the genetic factors, especially in the period of adrenarche. Therefore, genetic influence might be important in adrenarche-related metabolic disorders.
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Barquera, R.; Martínez-Álvarez, J.C.és.; Hernández-Zaragoza, D.I.íz.; Bravo-Acevedo, A.; Juárez-Nicolás, F.; Arriaga-Perea, A.ín.J.ó; Vega-Martínez, M.ía.D.R.; Ortega-Yáñez, A.; Benítez-Arvizu, G.; Arrieta-Bolaños, E.; Clayton, S.; Juárez-Cortés, E.D.; López-Gil, C.ón.; García-Álvarez, R.; Arrazola-García, M.ía.A.; Martínez-Bezies, V.; Juárez-Barreto, V.; Ramos-de la Cruz, F.D.R.ío.; Macías-Medrano, R.M.ía.; Méndez-Mani, P.; Escutia-González, A.; Montiel-Hernández, G.D.; Immel, A.; Pavón-Vargas, M.ía.d.L.Án.; Salgado-Galicia, N.; Novelo-Garza, B.ár.; Zúñiga, J.ín.; Yunis, E.J.; Bekker-Méndez, C.; Granados, J. 2020: Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City Human Immunology 81(9): 539-543
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