Linear porokeratosis of Mibelli in monozygotic twin girls
Guillot, P.; Taieb, A.; Fontan, I.; Bilhou-Nabera, C.; Viard, E.; Renaud, P.; Maleville, J.
Annales de Dermatologie et de Venereologie 118(8): 519-524
1991
ISSN/ISBN: 0151-9638 PMID: 1952688 Document Number: 378775
Two monozygotic female twins with linear porokeratosis of Mibelli are described. One had only minimal lesions of the right elbow. The other had a linear lesion of the right arm following Blaschko's lines. Monozygotism was established using DNA fingerprinting. A single-gene defect of variable expressivity involving the clonal development of epidermal cutaneous cells according to the lines of cutaneous embryogenesis is suspected. Dithranol and carbon dioxide laser treatment are discussed.