Successful treatment of thrombotic thrombocytopenic purpura with vincristine report of one case
Espinoza, F.; Leal, Jé.Luis.; Arenas, G.
Revista Medica de Chile 135(12): 1572-1576
2007
ISSN/ISBN: 0034-9887 PMID: 18357359 Document Number: 606731
Thrombotic thrombocytopenic purpura presents as a multisystemic disease with thrombocytopenia, microangiopathic hemolytic anemia, fever, neurological and renal involvement. We report a 24 years-old male presenting with purpura and a generalized seizure. His blood tests showed an hemolytic anemia, unconjugated hyperbilirubinemia, increased lactated dehydrogenase, thrombocytopenia and impairment of renal function. He was initially treated with daily plasmapheresis and steroids without improvement. Due to persistence of the disease, he was treated with two doses of intravenous vincristine in four days, with clinical and laboratory improvement. He was discharged 40 days after the last dose of vincristine, in good conditions.