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Metabolic changes in rat brain histaminergic neurons in dynamics of subhepatic cholestasis

Zimatkin, S.M.; Baraban, O.V.; Emel'ianchik, S.V.

Morfologiia 132(4): 27-30

2007

ISSN/ISBN: 1026-3543
PMID: 17969424
Document Number: 606674
The aim of the study was the estimation of metabolic changes in rat brain histaminergic neurons in dynamics of subhepatic cholestasis. The investigation was carried out in male Wistar rats using the quantitative histochemical methods. It was found that cholestasis induced significant changes in the activity of dehydrogenases of succinate, lactate, glucose-6-phosphate, NADH and NADPH, as well as of acid phosphatase and type B monoamine oxidase in hypothalamic histaminergic neurons. These changes depended on the duration of cholestasis and had the dynamic, undulating pattern. They were demonstrated already after 5 days of cholestasis, reached their maximum by 10-20 days, were decreased at 45 days and disappeared after 90 days.

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