In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions
Pál, A.; Kis, E.; Méhn, D.ór.; Glavinas, H.; Nagy, T.ün.; Mészaros, P.ét.; Báthori, G.ör.; Krajcsi, P.ét.; Falkay, G.ör.
Acta Pharmaceutica Hungarica 77(4): 205-216
2007
ISSN/ISBN: 0001-6659 PMID: 18290540 Document Number: 606672
ABCG2, a transporter of the ATP-binding cassette family, is known to play a prominent role in the absorption, distribution, metabolism, and excretion of xenobiotics. Drug-transporter interactions are commonly screened by in vitro systems using transfected insect and/or human cell lines.