The association of monoamine oxidase B functional polymorphism with postoperative pain intensity
Serý, O.; Hrazdilová, O.; Didden, W.; Klenerová, V.; Staif, R.; Znojil, Vír.; Sevcík, P.
Neuro Endocrinology Letters 27(3): 333-337
2006
ISSN/ISBN: 0172-780X PMID: 16807522 Document Number: 605105
The monoamine oxidase B (MAO-B) is an enzyme involved in metabolism of dopamine, benzylamine, phenylethylamine, tyramine and tryptamine. The A/G polymorphism in intron 13 of the MAO-B gene has been previously found to be associated with variability of the MAO-B enzyme activity. The aim of the present association study has been to examine the relationship between the A/G polymorphism in intron 13 and postoperative pain intensity. 284 subjects (105 males and 179 females) undergoing planned tonsillectomy were examined. The intensity of pain was evaluated using 100-mm visual analogue scale (VAS). A PCR method with allele specific primers for detection of A/G polymorphism was used. We found a relationship between the A/G polymorphism in intron 13 of the MAO-B gene and average intensity of postoperative pain in male subjects. Higher average intensity of postoperative pain was detected in males with the G allele (3.96) in comparison with males with the A allele (3.45) and the difference was statistically significant (p<0,03). Results of this study indicate the relationship between the MAO-B polymorphism and postoperative pain intensity in the Czech male population. A potential role of MAO-B in the perception of pain intensity is discussed.