Hexobarbital sleep in rats treated with polyvinylpyrrolidone
Ovcharov, R.; Kutsarova, T.; Popov, P.; Gruev, T.
Eksperimentalna Meditsina i Morfologiia 12(2): 97-99
1973
ISSN/ISBN: 0367-0643 PMID: 4806522 Document Number: 60289
Young male rats, breed Wistar, underwent daily intravenous injections with 10 ml per kilogram body weight polyvinyl pyrrolidone, over a period of five days. As a control group, non injected rats of the same age were used. The duration of sleep after interaperitoneal injection of hexobarbital natrium at dose 100 mg/kg weight was checked in both groups. It was established that in the animals treated with polyvinyl pyrrolidone the duration of sleep was shorter. In a second group of animals, treated with polyvinyl pyrrolidone, the concentration of aminopyrine N-demethylase in the liver was traced.