Pronostic value of the immunohistochemical expression of cyclin D1 (DCS6) in epidermoid larynx carcinoma
García Lozano, M.C.; Orradre Romero, J.L.; Sánchez Carrión, S.; Caro Garcia, M.; Lasso Luis, O.; Piris Pinilla, M.A.
Anales Otorrinolaringologicos Ibero-Americanos 33(3): 257-272
2006
ISSN/ISBN: 0303-8874 PMID: 16881553 Document Number: 602388
In this paper we carried out an immunohistochemical study of cyclin D1 (DCS6 ) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied cyclin D1 expression at this level. Furthermore we have analysed the value of cyclin D1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between cyclin D1 expression and other clinic and pathologic parameters.