Polyclonal plasma cell proliferation with marked hypergammaglobulinemia and multiple autoantibodies
Li, L.; Hsu, P.; Patel, K.; Saffari, Y.; Ashley, I.; Brody, J.
Annals of Clinical and Laboratory Science 36(4): 479-484
2006
ISSN/ISBN: 0091-7370 PMID: 17127739 Document Number: 602370
A 77-yr-old man presented with marked peripheral blood and bone marrow plasmacytosis, marked hypergammaglobulinemia, and multiple autoantibodies. Serum protein immunofixation and immunophenotyping of bone marrow plasma cells by flow cytometry and immunohistochemistry disclosed polyclonal proliferation of plasma cells at various stages of differentiation. The presence of multiple autoantibodies in the patient's serum suggests that an autoimmune disease underlies the polyclonal proliferation of plasma cells.