PPAR and NASH
Tanaka, N.; Aoyama, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 64(6): 1089-1094
2006
ISSN/ISBN: 0047-1852 PMID: 16768114 Document Number: 602340
The nuclear receptor peroxisome proliferator-activated receptor (PPAR) plays important roles in maintaining the homeostasis of lipids and glucose. Among three isoforms of PPAR, PPARa and PPARgamma are localized mainly in hepatocytes and adipocytes, respectively. Recently, it has been recognized that PPAR also modulates inflammatory responses, regulates cell division and associates with liver fibrogenesis and tumorigenesis. Although the roles of PPAR for the pathogenesis of nonalcoholic steatohepatitis (NASH) remain unclear, several data suggest the relationship between PPAR and the occurrence or progression of NASH. For example, in mice lacking acyl-CoA oxidase gene, which developed NASH spontaneously, the absence of PPARalpha prevented the development of NASH. Long term administration of PPARgamma activator pioglitazone ameliorated the activity of NASH. In this review, we summarize the evidences concerning NASH and PPAR in this time.