PPAR gamma: an essential role in metabolic control
Fajas, L.; Debril, M.B.; Auwerx, J.
Nutrition Metabolism and Cardiovascular Diseases Nmcd 11(1): 64-69
2001
ISSN/ISBN: 0939-4753 PMID: 11383325 Document Number: 538911
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.